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O G Ottmann Selected Research

PF-114

5/2015PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation.

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O G Ottmann Research Topics

Disease

13Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
07/2020 - 10/2002
12BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
04/2013 - 07/2000
9Leukemia
01/2017 - 07/2000
9Philadelphia Chromosome
05/2015 - 07/2000
6Residual Neoplasm
07/2020 - 09/2003
4Myelodysplastic Syndromes (Myelodysplastic Syndrome)
12/2017 - 05/2000
4Neoplasms (Cancer)
01/2016 - 04/2000
4Rheumatoid Arthritis
12/2007 - 03/2001
3Neutropenia
08/2013 - 10/2001
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2017 - 08/2004
2Hematologic Neoplasms (Hematological Malignancy)
08/2013 - 01/2013
2Hyperbilirubinemia
05/2012 - 11/2007
2Synovitis
12/2007 - 03/2001
2Refractory Anemia with Excess of Blasts (RAEM)
08/2004 - 10/2000
2Refractory Anemia
08/2004 - 05/2000
2Infections
10/2002 - 03/2000
2Acute Promyelocytic Leukemia
01/2001 - 07/2000
2HIV Infections (HIV Infection)
03/2000 - 03/2000
1Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic)
12/2017
1Lymphoma (Lymphomas)
08/2013
1Thrombocytopenia (Thrombopenia)
08/2013
1Fatigue
08/2013
1Mucositis
01/2013
1Alopecia (Baldness)
01/2013
1Hypophosphatemia
05/2012
1Carcinogenesis
06/2009
1Inflammation (Inflammations)
12/2007
1Sexually Transmitted Diseases (Sexually Transmitted Disease)
01/2004
1Graft vs Host Disease (Graft-Versus-Host Disease)
04/2003
1Blast Crisis (Blast Phase)
04/2003
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
10/2002
1Agranulocytosis (Granulocytopenia)
10/2002
1Colitis
10/2001
1Leukopenia
10/2001
1Fever (Fevers)
10/2001
1Spondylarthropathies
03/2001
1Necrosis
03/2001
1Myeloproliferative Disorders (Myeloproliferative Disorder)
07/2000
1Febrile Neutropenia
05/2000

Drug/Important Bio-Agent (IBA)

18Imatinib Mesylate (Gleevec)FDA Link
06/2013 - 10/2001
6nilotinibFDA Link
06/2013 - 11/2007
6Phosphotransferases (Kinase)IBA
08/2012 - 07/2000
4Tyrosine Kinase InhibitorsIBA
05/2015 - 10/2004
4Cytarabine (Cytosar-U)FDA LinkGeneric
08/2004 - 10/2002
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
07/2020 - 01/2019
2PanobinostatIBA
12/2017 - 08/2013
2Granulocyte Colony-Stimulating Factor (G-CSF)IBA
08/2004 - 10/2002
2Interferon-alpha (Interferon Alfa)IBA
12/2003 - 10/2003
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2001 - 05/2000
2Interleukin-18 (Interleukin 18)IBA
03/2001 - 03/2000
2CytokinesIBA
03/2001 - 05/2000
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
03/2001 - 05/2000
2promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA
01/2001 - 07/2000
1Azacitidine (5 Azacytidine)FDA Link
12/2017
1PlasticsIBA
01/2017
1ertumaxomabIBA
01/2016
1PF-114IBA
05/2015
1ponatinibIBA
05/2015
1Pharmaceutical PreparationsIBA
01/2013
1tozasertibIBA
01/2013
1Aurora KinasesIBA
01/2013
1Lipase (Acid Lipase)FDA Link
05/2012
1A-Form DNA (A-DNA)IBA
06/2009
1Insulin-Like Growth Factor II (Somatomedin A)IBA
12/2007
1Insulin-Like PeptidesIBA
12/2007
1Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA
11/2007
1BilirubinIBA
11/2007
1Uridine Diphosphate (UDP)IBA
11/2007
1TOR Serine-Threonine KinasesIBA
10/2005
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
10/2005
1Etoposide (VP 16)FDA LinkGeneric
08/2004
1Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric
08/2004
1Culture MediaIBA
01/2004
1Arabinofuranosylcytosine TriphosphateIBA
01/2004
1InterferonsIBA
12/2003
1Messenger RNA (mRNA)IBA
12/2003
1Interleukin-10 (Interleukin 10)IBA
11/2002
1Mitoxantrone (Novantrone)FDA LinkGeneric
10/2002
1InterleukinsIBA
09/2002
1Interleukin-6 (Interleukin 6)IBA
03/2001
1Interferon-gamma (Interferon, gamma)IBA
03/2001
1polyethylene glycol-recombinant human megakaryocyte growth and development factor (PEG-MGDF)IBA
10/2000
1Arsenic Trioxide (Trisenox)FDA Link
07/2000
1ArsenicIBA
07/2000
1Anti-Bacterial Agents (Antibiotics)IBA
05/2000
1Amifostine (Ethyol)FDA LinkGeneric
05/2000
1Histones (Histone)IBA
04/2000
1Histone Deacetylases (Histone Deacetylase)IBA
04/2000
1Histone Acetyltransferases (Histone Acetyltransferase)IBA
04/2000
1Catalytic RNA (Ribozymes)IBA
03/2000

Therapy/Procedure

8Therapeutics
01/2016 - 05/2000
5Stem Cell Transplantation
06/2013 - 12/2002
2Drug Therapy (Chemotherapy)
08/2012 - 08/2004
1Radiotherapy
08/2004
1Induction Chemotherapy
11/2003
1Salvage Therapy
09/2003
1Remission Induction
10/2002